Endocrine Abstracts

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Objective: Despite of conflicting data, reduced levels of endogenous sex hormones and especially sex hormone binding globulin (SHBG) seem to be associated with metabolic syndrome (MS). In this study we determined relationship between endogenous sex hormone levels and SHBG and components of metabolic syndrome in both sexes.Methods: In 39 men (median age 70.2) with total testosterone level in the lowest quartile of normal range (median 12.8 nmol/l) and 29 ...

Introduction: Weight loss is a key initial treatment strategy in obese women with polycistic ovary syndrome (PCOS) and improves insulin sensitivity and metabolic risk factors. In some women with PCOS it may reduce hyperandrogenism and restore menstrual function, ovulation and fertility. The aim of this study was to reveal clinical predictors of menstrual response to weight loss in overweight women with PCOS.Design: overweight unovulatory women with PCOS ...

Objective: Children with malignant disease are at increased risk of bone disorders, cardiovascular disease and further neoplasia. Vitamin D status may influence this risk and so we assessed Vitamin D levels in children with malignant disease undergoing active treatment or surveillance post-therapy.Study design: This was an outpatient-based cross-sectional study of 60 children with a history of malignancy (cases: median age 11.1 years; range 1.5–24.4...

Background: PCO is more prevalent among SA than C and IR is central to its pathogenesis; whilst Type 2 diabetes (DM) is commoner in SA. We compared the phenotype and IR in South Asian and Caucasians with PCOS.Methods: Comparison of consecutive anovular PCOS; 47 SA and 36 Caucasians and their age and weight matched controls (11 SA and 22 Cs).Results: SA presented earlier (age 26 plus/minus 4 v 30.1 plus/minus 5, p = 0.005). BMI (24....

We have previously shown that obese children with prior fracture have a lower bone mass for body size. We further hypothesised that obese children would fail to gain bone mass in relation to body size over a one-year period compared to lean controls.Methodology: Out of 103 children recruited into obese (BMI>98th percentile) and control (BMI<98th percentile) groups at baseline, 66 children aged 6.5–18 years returned at one year. Total body an...

Background: Endocrinology is a relatively young subspecialty of internal medicine. No consensus on international standards for training has been established, and hence the variability between training programs and endocrinologist qualifications may be great.Methods: A standardized questionnaire was constructed to explore individual national standards for endocrinology training, evaluating the responding programs for physician entry criteria for each prog...

Ghrelin, a novel GH-releasing n-octanoylated peptide, has been identified as an endogenous ligand for the 'orphan' GH secretagogue receptor. When administered iv or icv, Ghrelin causes a greater increase in serum GH concentrations than hexarelin or GHRH. However Ghrelin has a number of other actions: it promotes food intake, raises serum glucose and inhibits insulin secretion, increases ACTH and cortisol secretion and influences cardiac function.In orde...

Aim: We previously reported preliminary evidence that use of TRH with CRH during inferior petrosal sinus sampling (IPSS) in Cushing’s syndrome gave additional information about quality of pituitary venous sampling and significance of gradients. We now report long-term experience of this technique in 40 patients investigated 1993–2005. We used standard central:peripheral ratios (C:P) of 2:1 basally and 3:1 after stimulation to indicate pituitary secretion and intersin...

Objective: To identify a range of IGF-I values representative of growth hormone deficiency (GHD), which could be utilised to reduce the risk of 'functional' GHD in Pegvisomant treated acromegaly.Method: We analysed centrally measured IGF-I data from the KIMS European GHD database. We stratified this cohort into six gender based, age ranges and assessed IGF-I and IGF-I standard deviation scores (SDS).Results: Baseline measurements f...